Fermented Rice Germ Extract Ameliorates Abnormal Glucose Metabolism via Antioxidant Activity in Type 2 Diabetes Mellitus Mice

Rice germ is an abundant source of ferulic acid, which known for its anti-oxidant activity. This study aimed to evaluate the regulatory effects fermented rice extracts on hepatic glucose metabolism in C57BL/KsJ-db/db mice. was with Lactobacillus plantarum and extracted 30% ethanol (RG_30E) or 50% (RG_50E). Mice were fed modified AIN-93 diets containing acid 8 weeks. RG_50E significantly reduced food intake as well liver weight RG_30E improved homeostasis, indicated by fasting blood levels tolerance. Hepatic triglyceride total cholesterol decreased db/db mice RG_50E. The antioxidant capacity confirmed a decrease malondialdehyde increase superoxide dismutase expression genes related glycolysis gluconeogenesis regulated These results suggest that have potential regulate hypoglycemia type 2 diabetes